I got into programming on the DECSystem-10 in Fortran IV and Macro-11 at Worcester Tech in 1974, though I was actually writing programs in BASIC back in 1968 but didn't have access to a computer to run them on. Assembly language was my language of choice on multiple platforms, but I got hooked on Perl4 as a scripting language in the late 80's/early 90's. When Perl5 added classes, I ignored them. I was already using Java by that time too, and Java's classes were much more cleanly implemented, since it had them from the beginning.
I was using PHP primarily for its graphics capabilities in the late 90's, making bandwidth charts of the routers and switches at the Internet company I worked for. It also had SQL integration working well much earlier than other scripting languages. But when I met ESR at a Unix user's group meeting sometime arount 2000, he convinced me to switch to Python. I dropped Perl almost immediately, with gratitude. And over the years, PHP has bitten the dust too, since Python has caught up and exceeded it in both graphics (with PIL) and SQL capability. PHP has become such a bloated accumulation of cruft that I would never consider any code using it to be secure. Same with modern Perl.
I'd therefore recommend C#, Ruby, or Python. Java is still very useful also, especially in the mobile arena. And its similarities to, and compatibility with, Javascript makes it quite easy to learn, since if you're doing web work you need Javascript for the client-side coding.
As for what I'm doing now, it's part web coding (client-server apps using Javascript, Python, and Java), and part bioinformatics (Biopython).