From what I've read (other questions on the site, etc...) the vast majority of desktop systems have little-endian architectures, and Windows doesn't even support big-endian. Now I'm wondering if it's even worth the extra effort to deal with endianness for the small number of big-endian desktop systems (if there even are any) out there. The application in question is 64-bit only and portable (Windows and Linux) in case that's relevant.
A practical benefit of going exclusively little-endian would be saving on
htonl/ntohl conversions for network communication, allowing raw binary data to be sent directly (from the application to other instances of itself on a remote machine). The performance difference would be negligible, but reducing code complexity is quite attractive.
Is there a compelling reason to support big-endian on desktops? Are big-endian systems even being used for desktops these days?