On the macroscopic (i.e. non-quantum) level, things that we think of as "random" are in fact "chaotic." This means that minute perturbations can have non-minute effects on the outcome. For example, you could in theory accurately predict the outcome of a fair coin toss or a fair die toss, but this would take a ridiculous amount of calculation and a slight shift in the air currents would throw all of your calculations off. But the fact remains that in theory you could predict these outcomes, and so the processes aren't truly random.

As Southpaw Hare brought up, quantum effects **are** truly random, at least by our current reckoning in physics. An electron does not exist in any one place at any one time, instead the electron exists in a probabilistic cloud - at the quantum level, particles exist as both particles and waves. The Heisenberg Uncertainty Principle says that attempts to narrow down the location of an electron are doomed to failure; when you measure the electron's location then you affect its velocity (so the more accurately you know the electron's current position, the less accurately you know its subsequent position). I believe that random number generators based on radioactive decay are tapping into quantum uncertainty and are therefore truly random, but it's been a decade since I took a physics course and so radioactive decay may instead be a chaotic process.