Desktop. I need my keys to be where they are. When microsoft came out with that stupid "lets turn those Insert/home/pageup/delete/end keys around 90 degrees" I raged like never before in my life. Keep my damn keys where they are, I don't want your garbage. I want my Model-M keyboard I've been using since the days when Comodore roamed the earth. My keyboard gets a lot of wear and I end up replacing normal ones really frequently because the contacts break up.
I need more than one real monitor. I don't want to look at some tiny freaking screen, and I don't want to lug around a 24 inch screen beast that devours the battery life.
I don't want any special over-ridden "make MS Word open" BS keys. I don't need to hit F-Whatever and have my screens flicker around. I want a numpad. Don't screw with my freaking keyboard!!!!
I don't use the mouse often, but I'd sure as hell use one over the trackpad or that TrackPoint garbage. When I'm typing I don't want the side of my hand to touch the trackpad and suddenly the text cursor is all over the screen.
Why would you EVER use a laptop for something other than screwing around in class at college?